Variation of HbF and F-cell number with the G-gamma Xmn I (C-T) polymorphism in normal individuals.
نویسندگان
چکیده
منابع مشابه
Association between XmnI Polymorphism and HbF Level in Sickle Cell Disease Patients from Chhattisgarh
The γ(G)-158 (C→T) polymorphism plays important function in the disease severity of sickle cell anemia. The XmnI restriction site at -158 position of the γ(G)-gene is associated with increased expression of the γ(G)-globin gene and higher production of HbF. This study aims to determine the frequency of the different genotypes of the γ(G) Xmn I polymorphism in sickle cell anemia and sickle cell ...
متن کاملVariation in hemoglobin F production among normal and sickle cell adults is not related to nucleotide substitutions in the gamma promoter regions.
Single nucleotide substitutions in the promoter regions of the A gamma- and G gamma-globin genes have been associated with increased fetal hemoglobin (HbF) production. We wished to determine whether these or other unrecognized substitutions in the gamma promoter regions are responsible for the 20-fold variation in HbF production in sickle cell patients or normal adults. From a random sampling o...
متن کاملHemoglobin E-beta thalassemia: factors affecting phenotype.
The phenotype of E-beta-thalassemia is affected by several genetic factors. The aim of this study was to analyze severity of E-beta-thalassemia and correlate with HbE, HbF, E/F ratios, beta-mutation and Xmn I polymorphism. Thirty cases of E-beta-thalassemia (23 with childhood onset) were studied. HbE levels were quantitated by HPLC. Xmn1 polymorphism and beta-mutations were studied by PCR-RFLP ...
متن کاملVariation of fetal hemoglobin and F-cell number with the LCR-HS2 polymorphism in nonanemic individuals.
To the Editor: remains const t and seems to be under genetic control.' Available data suggest that at least two types of genetic determinants might In normal adults. synthesis of fetal hemoglobin (HbF) persists at be involved in the level of HbF expression: one linked to the pa very low level ( < I % ) and is restricted to a subpopulation of globin gene cluste?.' and the other(s) unlinke...
متن کاملFrequency of G-globin promoter -158 (C>T) Xmn I polymorphism in Denizli, Turkey
The effect of -158 (C>T) Xmn I polymorphism on expression of G-globin gene has been the subject of considerable interest. This study aims to determine the frequency of the G Xmn I polymorphism in thalassemia patients in Denizli province of Turkey. We studied Xmn I polymorphism in the DNA samples of 27 with -thalassemia major, 210 -thalassemia minor patients and 100 healthy subjects as the ...
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ورودعنوان ژورنال:
- Blood
دوره 79 3 شماره
صفحات -
تاریخ انتشار 1992